The first wooden church was built during the time of Patriarch Isdepanos II, through the benefaction of the imperial architect Hovhannes Amira Serveryan. It was later rebuilt in 1861 by Bogos Ağa Şalcıyan. Located across from the Kuzguncuk Pier, the church features a dome resembling that of the Surp Asdvadzadzin Church in Beşiktaş, though unlike the latter, its dome is clearly visible from the outside. Behind the altar stands a two-story bell tower crowned with a dome. In front of the altar, the walnut wood balustrades are decorated with floral and leaf motifs crafted by Kalust Ağa Kemhacyan, who at the time was the supplier of fine timber to the Ottoman palace. The interior of the Holy Table is domed and gilded.
In 1967, decorative embellishments were added to the interior of the church. Within the courtyard stands a fountain dating back to 1910.
The church underwent restoration in 2005 and was re-consecrated and reopened for worship by Patriarch Mesrob II.
Next to the northern wall rests Bishop Hovhannes Setyan (1800–1875), who once served as the preacher of the church.